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Most Recent Developments in Treatments for Alzheimer’s

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Many current Alzheimer’s medications are designed to slow the progress of symptoms. However, every year, researchers learn more and more about the underlying mechanisms that lead to Alzheimer’s development. Treatments recently developed in clinical trial research are designed to target particular mechanisms of the disease process.

Targeting Plaques

Solanezumab is a substance known as a monoclonal antibody. The medication mimics the body’s own antibodies and is thought to be useful in preventing the plaques formed by beta-amyloid proteins, which tangle and destroy neuron function. Although early trials demonstrated positive results, the medication hasn’t proven to be helpful in people with Alzheimer’s who have moderate to severe forms of the disease. Studies are currently underway to determine effectiveness during the early stages of the disorder.

In recent years, scientists discovered a new protein known as Fyn that interacts with beta-amyloid proteins. When activated, Fyn destroys the synapse pathways between neurons. Research involving the cancer formulation saracatinib is underway. Studies indicate the medication inhibits Fyn, which enables synapses to regain normal function. Clinical trials involving people with Alzheimer’s are currently in progress. 

If your loved one is diagnosed with Alzheimer’s disease, help is just a phone call away. Certain age-related conditions can make it more challenging for seniors to age in place safely and comfortably, but Bethlehem 24-hour care experts are available around the clock to help seniors manage their health. Whether your loved one is living with dementia or is recovering from a stroke, you can trust the professional live-in caregivers from Home Care Assistance to enhance his or her quality of life. 

Preventing Protein Entanglement

Tau proteins are another problem that contributes to Alzheimer’s development. The proteins congregate and stick together while adhered to neurons. Thus, the neurons become tangled and the pathways between them become destroyed. Researchers are currently studying the effects of tau aggregation inhibitors and vaccines to prevent the harmful action.

CBD Oil

Cannabidiol, which is often referred to as CBD, interacts with the endocannabinoid receptors in the body to produce various health benefits. However, the plant-based derivative doesn’t cause intoxicating effects. In 2017, a group of French scientists learned CBD oil effectively reduced the cellular inflammation and oxidative stress associated with the presence of abundant beta-amyloid proteins in the brains of people with Alzheimer’s. Their findings were published in an article in Acta Biochimica et Biophysica Sinica. A 2017 study performed by a group of researchers from Western Sydney University demonstrated CBD oil prevented neuron destruction and promoted neuron and synapse growth in laboratory animals afflicted with Alzheimer’s-like symptoms. 

Caring for a senior loved one can be challenging for families who don’t have expertise or professional training in home care, but this challenge doesn’t have to be faced alone. Family caregivers can turn to Bethlehem Home Care Assistance for the help they need. We provide high-quality live-in and respite care as well as comprehensive Alzheimer’s, dementia, stroke, and Parkinson’s care.

Heart-Brain Connection

Increasing evidence suggests cognitive health correlates with cardiovascular health. Diabetes, heart disease, elevated cholesterol levels, hypertension, and strokes have been shown to increase the risk of developing Alzheimer’s. In light of the connection, researchers are in the process of determining if keeping the cardiovascular system healthy also promotes brain health. Evidence suggests living a healthier lifestyle by eating a heart-healthy diet and getting regular exercise may play a major role in preventing Alzheimer’s. Blood pressure medications and other formulations used to treat cardiovascular disorders may also reduce the risk of cognitive impairment.

Hormone Therapy

Estrogen-based hormone therapy has demonstrated neuroprotective qualities when given to women entering menopause who also have a high risk of developing Alzheimer’s. Studies are in progress to determine the relationship between the hormone and cognitive function. 

There are many reasons seniors might need assistance at home. Some may require regular mental stimulation due to an Alzheimer’s diagnosis, while others might only need part-time assistance with exercise and basic household tasks. Home Care Assistance is a leading senior care provider. Families rely on our expertly trained caregivers to help their senior loved ones maintain a high quality of life. If your loved one needs assistance with the challenges of aging, reach out to one of our knowledgeable, compassionate Care Managers today at 484-350-3874.